Mix flour and Greek yogurt together in a bowl to form a dough; transfer to a work surface floured with self-rising flour. Knead dough, adding more flour as needed to keep dough from being too sticky, about 8 to 10 minutes.
Spray a 12 inch pizza pan with cooking spray and spread dough to the edges of the pan.
Bake the pizza crust for 5 to 7 minutes. Leave the oven on.
Add your favorite toppings and return to the oven. Bake until crust is lightly browned, 5 to 7 minutes more.